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Sepsis criteria?Initial care for acute MI?NYHA classification?

A 38-year-old woman has Hb 8.1, platelets 18,000, schistocytes, LDH 1,240, Cr 1.4, normal PT/aPTT, and confusion. Differentiate TTP from DIC and outline immediate management.

1:33 AM

Preparing an answer

These findings are highly consistent with thrombotic thrombocytopenic purpura (TTP) and make disseminated intravascular coagulation (DIC) less likely as the leading diagnosis.

Key distinction: Microangiopathic hemolytic anemia, severe thrombocytopenia, neurologic symptoms, and normal PT/aPTT strongly favor TTP.
Compared with DIC: DIC more often causes prolonged PT/aPTT, low fibrinogen, and elevated D-dimer; check these in parallel.
ADAMTS13 and PLASMIC: Draw ADAMTS13 before plasma therapy and calculate a PLASMIC score, but do not delay treatment for the result.
Immediate care: Obtain urgent hematology input, start plasma exchange and systemic steroids, and consider caplacizumab for suspected acquired TTP.

Clinical considerations:

Avoid platelet transfusion unless bleeding is life-threatening, and monitor cardiac, neurologic, and renal injury.
If a strong DIC trigger such as sepsis or an obstetric complication exists, evaluate and treat it concurrently.

Calculate the PLASMIC score?Review the first-hour steps?

1:33 AM

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Literature search in Alphadoc — **Find the evidence you need among thousands of papers.**Search medical literature from Korea and abroad, then review titles, sources, publication dates, and original articles together. The path from question to evidence review becomes one focused flow.

**Find the evidence you need among thousands of papers.**Search medical literature from Korea and abroad, then review titles, sources, publication dates, and original articles together. The path from question to evidence review becomes one focused flow.

9:41

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